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Convert vial amount to micrograms (if needed): mg 1,000 = mcg Concentration: total amount (mcg) total liquid (mL) = mcg/mL Draw volume: target amount (mcg) concentration (mcg/mL) = mL U100 units: mL 100 = syringe units Worked example (math only) If a vial is labelled 50 mg (50,000 mcg) and you add 10 mL, the concentration is 5,000 mcg/mL

Some research suggests they might affect prostaglandin synthesis, which could potentially influence smooth muscle contraction in the intestinal wall and alter gut transit time, though this effect is generally modest at recommended doses and the evidence is not conclusive

Ascha et al

A missed dose should be administered the following evening at the usual time